Researchers Outline Multifactorial Considerations for Acne Treatment in Transgender Patients Receiving Testosterone


Throughout their paper, researchers highlighted acne treatment for these patients often involves other considerations—including reproductive health and mental health—and dermatologists should keep these in mind when making decisions for each patient.

A new article offered guidance for clinicians treating acne in their transgender patients receiving testosterone therapy. As a common side effect of gender-affirming testosterone, acne can significantly impact quality of life by impairing body image and mental health.

Throughout their paper, the researchers highlighted that acne treatment for these patients often involves other considerations, such as reproductive health and mental health. They noted dermatologists should keep these in mind when making decisions for each patient.

“There is no current evidence-based guideline on the best practices for treating hormonal acne in the context of testosterone therapy. Current treatment regimens for hormonal acne have been extrapolated from acne treatment guidelines designed for cisgender persons not receiving testosterone,” explained the researchers.

“Acne treatment planning depends on multiple factors such as the predominant acne lesion type, physician- and patient-assessed severity, presence of post-inflammatory erythema, dyspigmentation or scarring, and psychological distress,” they said.

Treatment options include mild acne treatments, moderate to severe acne treatments and contraceptive considerations, and isotretinoin with multidisciplinary considerations.

Mild acne treatments consist of topical retinoids indicated for mild and moderate comedonal and inflammatory acne, such as adapalene and trifarotene. The latter is the only topical retinoid approved for truncal acne, which the researchers said may be more prevalent in patients with acne stemming from testosterone therapy. Other mild treatments include topical benzoyl peroxide and topical antibiotics, as well as topical antiandrogen, such as clascoterone….



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